Association of insomnia severity and comorbid medical and psychiatric disorders in a health plan-based sample: insomnia severity and comorbidities. Sarsour K, Morin CM, Foley K, Kalsekar A, Walsh JK. Insomnia and its relationship to health-care utilization, work absenteeism, productivity and accidents. 2007 30:263–73.ĭaley M, Morin CM, LeBlanc M, Grégoire JP, Savard J, Baillargeon L. The direct and indirect costs of untreated insomnia in adults in the United States. Public health impact and treatment of insomnia. This work establishes a model to investigate the neurobiological basis of CBT-I, and provides a platform that can be exploited toward novel treatment targets for insomnia.ĭement W, Pelayo R. We apply this sleep opportunity restriction paradigm to aging and Alzheimer’s disease fly models, and find that sleep impairments in these models are reversible with sleep restriction, with associated improvement in reproductive fitness and extended lifespan. The response to sleep opportunity restriction requires ongoing environmental inputs, but is independent of the molecular circadian clock. We demonstrate that restriction of sleep opportunity through manipulation of environmental cues improves sleep efficiency in multiple short-sleeping Drosophila mutants. Here, guided by human behavioral sleep therapies, we developed a Drosophila model for sleep restriction therapy (SRT) of insomnia. Despite the well-documented efficacy of CBT-I, little is known regarding how CBT-I works at a cellular and molecular level to improve sleep, due in large part to an absence of experimentally-tractable animals models of this intervention. Cognitive behavioral therapy for insomnia (CBT-I) is the first-line treatment for insomnia a key component of this intervention is restriction of sleep opportunity, which optimizes matching of sleep ability and opportunity, leading to enhanced sleep drive. Insomnia is also a common comorbidity across psychiatric disorders. Insomnia is the most common sleep disorder among adults, especially affecting individuals of advanced age or with neurodegenerative disease.
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